2013 Fiscal Year Final Research Report
The relationship between Peyer's Paches and intestinal polyps
| Project/Area Number |
23650631
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cancer epidemiology and prevention
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 遺伝子環境交互作用 / 腸管腫瘍 / パイエル板 |
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| Research Abstract |
The aim of this experiment is to clarify the interaction between the function of Peyer's Patches(PP), which play a central role in intestinal immunity, and intestinal polyp formation.We found a statistically significant inverse correlation between the number of PP and that of intestinal polyps in ApcMin/+ mice which are known as the model of human colorectal cancer. We, then, tried to increase the number of PP artificially by feeding the Corn Husk Arabinoxylan (CHAX), and examined polyp formation.
The number of intestinal polyps was decreased statistically when the number of PP in intestine was increased by feeding the CHAX. On the contrary, there was no significant difference in Aly-/-ApcMin/+ mice which have no PP in intestine when the mice fed with or without CHAX.
Since PP has been playing the central role of a gut immunity system, we investigated the change of cytokine in serum. We revealed that IL-1beta, IL-5, IL-10 and IL-17 were decreased when the ApcMin/+ mice fed the CHAX.
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