2011 Fiscal Year Final Research Report
Molecular mechanism of radiation/NBS1-associated microcephaly
| Project/Area Number |
23651045
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
KOMATSU Kenshi 京都大学, 放射線生物研究センター, 教授 (80124577)
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| Project Period (FY) |
2011
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| Keywords | 感受性 |
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| Research Abstract |
The incidence of radiation microcephaly is 10-fold higher than that of radiation carcinogenesis. We showed her that radiation induces the apoptosis in basal neuro-progenitor cells, and develops radiation microcephaly. Simultaneously, apoptosis was observed in apical neuro-progenitor cells, which produce basal neuro-progenitor cells by cell proliferation through attachment of centrosomes to apical layers. These evidences suggest that proliferation is critical to develop radiation apososis, because defect in maintaining centrosomes induces the microcephaly in a patient with Nijmege breakage syndrome.
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[Journal Article] NBS1 recruits RAD18 via a RAD6-like domain and regulates Polη-dependent translesion DNA synthesis2011
Author(s)
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K
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Journal Title
Mol Cell
Volume: 43
Pages: 788-797
DOI
Peer Reviewed
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[Presentation] he roles of NBS1 in responses to radiation-and UV-induced DNA damage2012
Author(s)
Kenshi Komatsu, Kyosuke Nakamura, Akihiro Kato, Junya Kobayashi, Hiromi Yanagihara, Douglas V. N. P. Oliveira, Mikio Shimada, Satoshi Tashiro, Shinya Matsuura, Toshio Mori, Hiroshi Tauchi
Organizer
The Sugahara Memorial International Symposium
Place of Presentation
Kyoto
Year and Date
2012-01-25
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