2012 Fiscal Year Final Research Report
Establishment of spatio-temporal analysis for low-dose-rateradiation-induced damage accumulation in tissue stem cells
| Project/Area Number |
23651051
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | 一般財団法人電力中央研究所 (2012)
Central Research Institute of Electric Power Industry (2011) |
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Principal Investigator |
OTSUKA Kensuke 一般財団法人電力中央研究所, 原子力技術研究所, 主任研究員 (50371703)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 放射線 / 組織 / 細胞 / 癌 / 発生 / 分化 / 遺伝子 / 幹細胞 / 低線量 / 腸管 |
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| Research Abstract |
Radiation-induced turnover of tissue stem cells was evaluated by genetic lineagetracing of intestinal tissue stem cells (Lgr5+ stem cells). X-rays induced loss of Lgr5+stem cells and reduced Lgr5 gene expression in the colon but not in the duodenum. Lossof colonic Lgr5+ stem cells seemed to be compensated by de novo production of Lgr5+ stemcells. These findings are important evidences to understand radiation-inducedcarcinogenesis.
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