• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Investigationof mechanisms of radical oxygen species (ROS) via ATP・ATP receptor signaling in the cells exposed to nanoparticles

Research Project

  • PDF
Project/Area Number 23651055
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTokyo University of Science

Principal Investigator

KOJIMA Shuji  東京理科大学, 薬学部, 教授 (90119579)

Project Period (FY) 2011 – 2012
Keywordsナノ粒子 / 活性酸素 / 環境科学 / ATP受容体 / 細胞毒
Research Abstract

The mechanism of ROS production via ATP-ATP signaling was examined in the mouse kidney mesangium cells exposed to nano-silica particles with 30, 70, and 300nm of diameter (nSP30, nSP70, and nSP300, respectively). As a result, the significant ATP release, Ca2+influx and ROS production were observed in the cells exposed to nSP30 and nSP70. These events were blocked by the treatment with ecto-nucleotidase apyrase, suggesting involvement of ATP・ATP receptor signaling in nSP-induced ROS production. Furthermore, the same results were obtained in human keratinocytes, HaCaT cells.

  • Research Products

    (4 results)

All 2013 2012

All Presentation (4 results)

  • [Presentation] ナノシリカ粒子により誘導されるATPシグナ リング2013

    • Author(s)
      長倉千尋、月本光俊、小島周二
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      20130300
  • [Presentation] ナノ シリカ粒子により誘導されるATPシ グナリングの解析2012

    • Author(s)
      長倉千尋、月本光俊、小島周二
    • Organizer
      第56日本薬学会 関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      20121000
  • [Presentation] 肝クッ パー細胞に対するナノ粒子の生物影響2012

    • Author(s)
      根岸祐介、月本光俊、小島周二
    • Organizer
      第56日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      20121000
  • [Presentation] Purinergic signalingを介したクッパー細胞でのナノシリカ粒子によるIL-1βの誘導2012

    • Author(s)
      根岸祐介、月本光俊、武之内敬人、木谷 裕、原田均、武田健、小島周二
    • Organizer
      フォーラム2012 衛生薬学環境・トキシコロギー
    • Place of Presentation
      名古屋
    • Year and Date
      20121000

URL: 

Published: 2014-09-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi