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2012 Fiscal Year Final Research Report

S100A8/A9 as a new mediator of arsenic toxicity

Research Project

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Project/Area Number 23651056
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTokushima Bunri University

Principal Investigator

HIMENO Seiichiro  徳島文理大学, 薬学部, 教授 (20181117)

Research Collaborator SUMI Daigo  徳島文理大学, 薬学部, 准教授
SHIMIZU Yuri  徳島文理大学, 薬学部, 大学院生
KHALED Hossain  バングラデシュ国立ラッシャイ大学, 生化学分子生物学科, 教授
Project Period (FY) 2011 – 2012
Keywordsヒ素 / 毒性 / 免疫 / S100A8 / S100A9
Research Abstract

S100A8/A9 proteins are known to be involved in inflammation and cancer immunity. We showed that exposure to arsenic induces expression of S100A9 in various types of cells and that transcription factor Nrf2 is involved in enhanced transcription of S100A9 gene. We also detected high concentrations of S100A8/A9 among the residents living in arsenic-endemic areas in Bangladesh, suggesting an important role of S100A8/A9 in arsenic intoxication.

  • Research Products

    (7 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results)

  • [Journal Article] Increases in oxidized low density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high density lipoprotein in the individuals exposed to arsenic in Bangladesh.2013

    • Author(s)
      Karim, M. R., Rahman, M., Islam, K., Mamun, A. A., Hossain, H., Hossain, E., Aziz, A., Yeasmin, F., Agarwal, S., Saud, Z. A., Nikkon, F., Hossain, M., Mandal, A.,Jenkins, R. O., Haris, P. I., Miyataka, H., Himeno, S., and Hossain, K.
    • Journal Title

      Toxicol. Sci

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Involvement of Nrf2 activation in the upregulation of S100A9 by exposure to inorganic arsenite.2013

    • Author(s)
      Sumi, D., Shimizu Y., Himeno S.
    • Journal Title

      Int. J. Mol. Med.

      Volume: 31(1) Pages: 259-264

    • DOI

      DOI:10.3892/ijmm.2012.1185

    • Peer Reviewed
  • [Journal Article] Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic.2012

    • Author(s)
      Hossain E, Islam K, Yeasmin F, Karim MR,Rahman M, Agarwal S, Hossain S, Aziz A, Al Mamun A, Sheikh A, Haque A, Hossain MT, Hossain M, Haris PI, Ikemura N, Inoue K, Miyataka H, Himeno S, Hossain K.
    • Journal Title

      Toxicol. Appl. Pharmacol.

      Volume: 259(2) Pages: 187-194

    • DOI

      doi.org/10.1016/j.taap.2011.12.023

    • Peer Reviewed
  • [Journal Article] Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh.2011

    • Author(s)
      Islam, K., Haque, A., Karim, M. R., Fajol, A.,Hossain, E., Salam, K. A., Ali, N., Saud, Z. A., Rahman, M., Rahman, M., Sultana, P., Hossain, M., Akhand, A.A., Mandal, A., Miyataka, H., Himeno, S., Hossain, K.
    • Journal Title

      Environ. Health

      Volume: 10(1), 64 Pages: 1-11

    • DOI

      doi:10.1186/1476-069X-10-64

    • Peer Reviewed
  • [Journal Article] Chronic exposure to arsenite induces S100A8and S100A9 expression in rat RBL-2H3 mast cells.2011

    • Author(s)
      Shimizu, Y., Fujishiro, H., Matsumoto, K., Sumi, D., Satoh, M., Himeno, S.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 36(1) Pages: 135-139

    • DOI

      doi.org/10.2131/jts.36.135

    • Peer Reviewed
  • [Presentation] 亜ヒ酸がマスト細胞の応答性と遺伝子発現に及ぼす影響2012

    • Author(s)
      姫野誠一郎、清水由里、角大悟.
    • Organizer
      第18回ヒ素シンポジウム.
    • Place of Presentation
      宮崎
    • Year and Date
      20121124-25
  • [Presentation] バングラデシュヒ素汚染地域住民の毛髪、爪、尿、および飲用水のヒ素濃度の分析2011

    • Author(s)
      池村憲明,井上潔,宮高透喜,姫野誠一郎.
    • Organizer
      第22回日本微量元素学会.
    • Place of Presentation
      京都
    • Year and Date
      20110700

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Published: 2014-09-25  

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