2012 Fiscal Year Final Research Report
S100A8/A9 as a new mediator of arsenic toxicity
Project/Area Number |
23651056
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Tokushima Bunri University |
Principal Investigator |
|
Research Collaborator |
SUMI Daigo 徳島文理大学, 薬学部, 准教授
SHIMIZU Yuri 徳島文理大学, 薬学部, 大学院生
KHALED Hossain バングラデシュ国立ラッシャイ大学, 生化学分子生物学科, 教授
|
Project Period (FY) |
2011 – 2012
|
Keywords | ヒ素 / 毒性 / 免疫 / S100A8 / S100A9 |
Research Abstract |
S100A8/A9 proteins are known to be involved in inflammation and cancer immunity. We showed that exposure to arsenic induces expression of S100A9 in various types of cells and that transcription factor Nrf2 is involved in enhanced transcription of S100A9 gene. We also detected high concentrations of S100A8/A9 among the residents living in arsenic-endemic areas in Bangladesh, suggesting an important role of S100A8/A9 in arsenic intoxication.
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Research Products
(7 results)
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[Journal Article] Increases in oxidized low density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high density lipoprotein in the individuals exposed to arsenic in Bangladesh.2013
Author(s)
Karim, M. R., Rahman, M., Islam, K., Mamun, A. A., Hossain, H., Hossain, E., Aziz, A., Yeasmin, F., Agarwal, S., Saud, Z. A., Nikkon, F., Hossain, M., Mandal, A.,Jenkins, R. O., Haris, P. I., Miyataka, H., Himeno, S., and Hossain, K.
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Journal Title
Toxicol. Sci
Volume: (in press)
Peer Reviewed
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[Journal Article] Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic.2012
Author(s)
Hossain E, Islam K, Yeasmin F, Karim MR,Rahman M, Agarwal S, Hossain S, Aziz A, Al Mamun A, Sheikh A, Haque A, Hossain MT, Hossain M, Haris PI, Ikemura N, Inoue K, Miyataka H, Himeno S, Hossain K.
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Journal Title
Toxicol. Appl. Pharmacol.
Volume: 259(2)
Pages: 187-194
DOI
Peer Reviewed
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[Journal Article] Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh.2011
Author(s)
Islam, K., Haque, A., Karim, M. R., Fajol, A.,Hossain, E., Salam, K. A., Ali, N., Saud, Z. A., Rahman, M., Rahman, M., Sultana, P., Hossain, M., Akhand, A.A., Mandal, A., Miyataka, H., Himeno, S., Hossain, K.
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Journal Title
Environ. Health
Volume: 10(1), 64
Pages: 1-11
DOI
Peer Reviewed
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[Journal Article] Chronic exposure to arsenite induces S100A8and S100A9 expression in rat RBL-2H3 mast cells.2011
Author(s)
Shimizu, Y., Fujishiro, H., Matsumoto, K., Sumi, D., Satoh, M., Himeno, S.
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Journal Title
J. Toxicol. Sci.
Volume: 36(1)
Pages: 135-139
DOI
Peer Reviewed
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