2012 Fiscal Year Final Research Report
Immobilization of antibodies on Eu-doped hydroxyapatite nanocrystals and their application for a rapid diagnosis of cancer
| Project/Area Number |
23651108
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
TANAKA Junzou 東京工業大学, 大学院・理工学研究科, 教授 (10343831)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ナノ機能材料 / バイオイメージング / 水酸アパタイト / ナノ結晶 / 発光 |
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| Research Abstract |
Bio-imaging techniques to visualize specific cancer cells are important for diagnosis and medical treatments. Luminescent nano-materials with high biocompatibility, which can emit under excitation of visible light, are desired for the medical applications. In this study, luminescent Eu(III) doped hydroxyapatite nanocrystals were synthesized by a wet chemical method. A 3-aminopropyltriethoxysilane (APTES) molecule was immobilized on the surface, and then folic acid (FA), a specific cancer cell-binding molecule, was bonded to the amino groups of APTES. No differences of luminescent spectra were detected for the nanocrystals though the processes of immobilization of APTES and FA.
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