• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Development of the new detection method for 5-hydroxymethylcytidine in genomic DNA

Research Project

  • PDF
Project/Area Number 23651188
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Genome biology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

HANAMI Takeshi  独立行政法人理化学研究所, LSA要素技術開発ユニット, 研究員 (60392073)

Co-Investigator(Kenkyū-buntansha) ITOH Masayoshi  独立行政法人理化学研究所, オミックス制御研究ユニット, ユニットリーダー (90344027)
Project Period (FY) 2011
Keywords5-ヒドロキシメチルシチジン / 化学変換 / 配列決定
Research Abstract

DNA oligomer containing 5-hmdC is react with protecting reagent with solvation to the aprotic solvent in the presence of long chain alkyl ammonium salt. The result showed that 5-hmdC is protected selectively by bridging 4'-amine and 5'-hydroxymethyl group. This protection group is stable under the condition of deamination reaction.

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi