2013 Fiscal Year Final Research Report
Investigation on interactive development of gut microbiota and immune system in infancy
| Project/Area Number |
23651207
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied genomics
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKAYMA Jiro 九州大学, (連合)農学研究科(研究院), 准教授 (40217930)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腸内細菌叢 / アレルギー / 腸管免疫 / 次世代シーケンサー / 16S rRNA / 前向き調査研究 / バクテロイデス / IL-23 |
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| Research Abstract |
Bacteria colonizing in digestive tract in early infancy must have great influence on the development of host immune system but still largely in question. In this research, we performed prospective study on the correlation between gut microbiota in infancy and later allergy development. As a result, we found that genus Bacteroides was more colonized in infants who developed any allergy disease within two years than infants who did not develop any allergy in the same duration. Next, we examined the effect of Bacteroides on dentritic cells in mouse Peyer's patch in ex vivo experiment and found that Bacteroides cells strongly induced transcription of IL-23 p19. Since IL-23 is a pro-inflammatory cytokine, this induction by Bacteroides may associate with the allergy development in later life.
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[Journal Article] Up to species-level community analysis of human gut microbiota by 16S rRNA amplicon pyrosequencing2013
Author(s)
Nakayama, J., Jiang, J., Watanabe, K., Chen, K., Ninxin, H., Matsuda, K., Kurakawa, T., Tsuji, H., Sonomoto, K., and Lee, Y.-K
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Journal Title
Bioscience Microflora Food Health
Volume: 32
Pages: 69-76
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[Presentation] アジア人の腸内フローラに見られる2つのエンテロタイプと地域特異性2014
Author(s)
東佳那子, Jiahui Jiang, 渡辺幸一, Shirchin Demberel, Sunee Nitisinprasert, Yongha Park, Endang S, Rahayum, Fa-Zheng Ren, Ying-Chieh Tsai, 園元謙二, Yuan-Kun Lee, 中山二郎
Organizer
日本農芸化学会 2014年度大会
Place of Presentation
東京
Year and Date
2014-03-29
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[Presentation] アジア5ヶ国児童の腸内細菌叢解析2013
Author(s)
Jiro Nakayama, Jiahui Jiang, Koichi Watanabe, Kazunori Matsuda, Takashi Kurakawa, Hirokazu Tsuji, Fa-Zheng Ren, Sunee Nitisinprasert, Endang S, Rahayum Chii-Cherng Liao, Ying-Chieh Tsai, Yuan-Kun Lee
Organizer
第17回腸内細菌学会
Place of Presentation
東京
Year and Date
2013-06-13
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[Presentation] Phase I study of Asian Microbiome Project : Discovery of intestinal microbiota in Asian youngsters profiled bu 16S rRNA gene pyrosequencing2013
Author(s)
Jiang J, Nakayama J, Watanabe K, Sakamoto N, Matsuda K, Kurakawa T, Tsuji H, Ren FZ, Nitisinprasert S, Rahayu ES, Liao CC, Tsai YC, Lee YK
Organizer
日本農芸化学会 2013年度大会
Place of Presentation
仙台
Year and Date
2013-03-26
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[Presentation] Asian Microbiome Project : A pilot study on the basal microbiota profile of healthy Asian youngsters2012
Author(s)
Nakayama J, Watanabe K, Sakamoto N, Jiang J, Matsuda K, Kurakawa T, Tsuji H, Ren FZ, Nitisinprasert S, Rahayu ES, Liao CC, Tsai YC, Lee YK
Organizer
International Human Microbiome Conference
Place of Presentation
パリ France
Year and Date
20120300
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[Presentation] Diversity of intestinal microbiota in Asian younsters profiled by 16S rRNA pyrosequencing2012
Author(s)
Jiang J, Nakayama J, Watanabe K, Sakamoto N, Matsuda K, Kurakawa T, Tsuji H, Ren FZ, Nitisinprasert S, Rahayu ES, Liao CC, Tsai YC, Lee YK
Organizer
第35回日本分子生物学会
Place of Presentation
福岡
Year and Date
2012-12-13
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[Presentation] 454 Pyrosequencing study on the basal microbiota of healthy Asian youngsters2012
Author(s)
Jiang J, Nakayama J, Watanabe K, Sakamoto N, Matsuda K, Kurakawa T, Tsuji H, Ren FZ, Nitisinprasert S, Rahayu ES, Liao CC, Tsai YC, Lee YK
Organizer
3rd Asain Symposium on Lactic Acid Bacteria
Place of Presentation
Wuxi China
Year and Date
2012-05-30
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[Presentation] ASIAN MICROBIOME PROJECT2011
Author(s)
Yuan Kun Lee, Jiro Nakayama, Fazheng Ren, Sunee Nitisinprasert, Endang Rahayu, Raha Abdul Rahim, Chii Cherng Liao, Koichi Watanabe, Ying Chieh Tsai
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
札幌
Year and Date
20110900
Invited
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