2012 Fiscal Year Final Research Report
Rational design of synthetic signaling activators by subcellular targeting of protein ligands
| Project/Area Number |
23651214
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Nagaoka University of Technology |
|---|
Principal Investigator |
TSUKIJI Shinya 長岡技術科学大学, 産学融合トップランナー養成センター, 特任准教授 (40359659)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 生物活性分子の設計 / 合成 |
|---|
| Research Abstract |
In this work, we have designed and created synthetic self-localizing ligands that spontaneously localize to specific organelles or membrane regions in living cells. Using the ligands and protein engineering, we have developed a new cell control method that allows conditional induction of protein translocation and cell signaling in mammalian cells.
|
Research Products
(12 results)
