2012 Fiscal Year Final Research Report
Rational design of synthetic signaling activators by subcellular targeting of protein ligands
| Project/Area Number |
23651214
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Nagaoka University of Technology |
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Principal Investigator |
TSUKIJI Shinya 長岡技術科学大学, 産学融合トップランナー養成センター, 特任准教授 (40359659)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生物活性分子の設計 / 合成 |
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| Research Abstract |
In this work, we have designed and created synthetic self-localizing ligands that spontaneously localize to specific organelles or membrane regions in living cells. Using the ligands and protein engineering, we have developed a new cell control method that allows conditional induction of protein translocation and cell signaling in mammalian cells.
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