2012 Fiscal Year Final Research Report
Development and application of novel calcium-sensitive protein splicing systems
| Project/Area Number |
23651216
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto University |
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Principal Investigator |
FUTAKI Shiroh 京都大学, 化学研究所, 教授 (50199402)
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| Project Period (FY) |
2011 – 2012
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| Keywords | カルシウムイオン / カルモジュリン / イオンチャネル |
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| Research Abstract |
Calmodulin C-terminal domain peptides formed a heterodimer in the presence of calcium. Aiming at its application to protein splicing, detailed modes of heterodimer formation of these peptides are under study. On the other hand, an ion-channelprotein was constructed using the calmodulin C-terminal segment. The channel opened in the presence of calcium, and thus artificial calcium-sensitive ion channel was successfully established.
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