2012 Fiscal Year Final Research Report
Supramolecular Assembly of Amphiphilic Mesogenic Compounds InducingApoptosis in a Human Solid Cancer Cell Line
| Project/Area Number |
23651229
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 医薬品探索 / 液晶 / 分子認識 / がん / アポトーシス |
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| Research Abstract |
We investigated anti-cancer activity of mesogenic compounds possessing a hydroxyl group. The compounds were tested against A549 human lung adenocarcinoma cell line. Three ring heterocyclic derivatives containing a phenol unit showed significant suppression of the cell growth. The cell cycle analysis indicates that these compounds induce apoptosis. To determine the influence of these derivatives on normal cells, they were tested against WI-38 human lung fibroblast cell line under the same condition. Very interestingly, suppression of the normal cells was found to be dependent on the core structure of the mesogenic moiety. Some compounds induces apoptosis selectively against the tumor cell without suppressing the normal cell.
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