Search for selective inhibitors of liver-type glycogen phosphorylase

2014 Fiscal Year Final Research Report

• Project/Area Number: 23651241
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemical biology
• Research Institution: Osaka Prefecture University
• Principal Investigator: MAKINO Yasushi 大阪府立大学, 理学(系)研究科(研究院), 助教 (70332955)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: グリコーゲンホスホリラーゼ / 阻害剤

Outline of Final Research Achievements

Glycogen phosphorylase (GP) is a typical allosteric enzyme with several different ligand-binding sites, thus offering multiple opportunities for inhibition of the catalytic activity. Characterization of the properties of these sites indicated that the GP storage site does not directly affect the action of the GP catalytic site. In the GP catalytic site, there are two subsites, which might play important roles in the catalytic action of GP. However, I could not find a selective inhibitor of liver-type GP.

Free Research Field

生体分子科学