2012 Fiscal Year Final Research Report
Mathematical framework for pattern formation of biological systems
| Project/Area Number |
23654036
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General mathematics (including Probability theory/Statistical mathematics)
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOBAYASHI Ryo 広島大学, 大学院・理学研究科, 教授 (60153657)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Takashi 京都大学, 大学院・医学研究科, 准教授 (10324617)
TERO Atsushi 九州大学, 数理学研究院, 准教授 (60431326)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 形態形成 / 自律分散 / 血管リモデリング / 肺の分岐構造 / 数理モデル |
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| Research Abstract |
Biological pattern formation is linked to its functionality, and it is quite different from patterns of non-living system. We are trying to construct a mathematical framework to describe biological pattern formations. In this research, we selected pattern formation of lung and remodeling of vascular network as themes, and studied these systems from the point of view of autonomous decentralized system. Concentration of FGF10 in the former and sear stress and pressure of the blood in the latter are the key information, and cells correspond to these local information. Our mathematical model could reproduced functional networks in each case.
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