Statistical physics of dynamical transitions in ES cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 23654147
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biophysics/Chemical physics
• Research Institution: Nagoya University
• Principal Investigator: SASAI Masaki 名古屋大学, 工学(系)研究科(研究院), 教授 (30178628)
• Co-Investigator(Renkei-kenkyūsha): TERADA Tomoki 名古屋大学, 大学院工学研究科, 准教授 (20420367) ; CHIKENJI George 名古屋大学, 大学院工学研究科, 助教 (10420366)
• Research Collaborator: WANG Jin New York州立大学, Stony Brook校, 准教授
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 遺伝子ネットワーク / ES細胞 / 揺らぎ / 国際情報交換アメリカ

Outline of Final Research Achievements

Much interest has been focused on the mechanism and biological meaning of large flucutuation of gene expression pattern observed in mouse embryonic stem cells (mESC). In this study, six genes including core genes to maintain pluripotency in mESC were selected and a theoretical model of the regulatory network among those six genes was constructed. Dynamical behavior of the network was analyzed by performing stochastic simulations, which led to the hypothesis that the slow conformational fluctuation of chromatins around gene loci explains the observed large fluctuation of gene expression pattern in mESC.

Free Research Field

理論生物物理学