2012 Fiscal Year Final Research Report
Construction of Medium-Sized Ring Compounds through Molecular Folding
| Project/Area Number |
23655025
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAWAMURA Masaya 北海道大学, 大学院・理学研究院, 教授 (40202105)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 中員環 / 金触媒 / 触媒設計 / 炭素結合 / 環状化合物 / 複素環化合物 / アルキン / ホスフィン配位子 |
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| Research Abstract |
A cationic gold(I) complex bearing a semihollow-shaped triethynylphosphine ligand efficiently catalyzed cyclizations of various alkynes tethered to different nucleophilic functional groups such as alcohols, sulfonamides, and silyl enol ethers due to an entropy-based rate enhancement. Trityl-based semihollow triethynylphosphines were synthesized and employed as ligands in the gold-catalyzed 8-exo-dig cyclization of acetylene-tethered silyl enol ethers to obtain eight-membered-ring carbocycles.
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