2012 Fiscal Year Final Research Report
Construction of Artificial Biocatalysts containing Non-natural Dimetallic Active Site
| Project/Area Number |
23655050
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
ONODA Akira 大阪大学, 大学院・工学研究科, 助教 (60366424)
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| Co-Investigator(Renkei-kenkyūsha) |
TAHASHI Takashi 大阪大学, 大学院・工学研究科, 教授 (20222226)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生物無機化学 / タンパク質 / 人工金属タンパク質 / 二核中心 |
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| Research Abstract |
Metalloenzymes catalyze variety of reactions including hydroxylation of methane and nitrogen fixation, which are difficult for synthetic catalysts, in mild conditions. Thus, the active site of these metalloenzyme has been attracted the chemists. In this project, the artificial biocatalysts containing non-natural dimetallic active sites were constructed.The first coordination shell of the active site was reengineered and the second coordination shell was redesigned. The structure and function of the resultant artificial biocatalysts were studied.
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