2012 Fiscal Year Final Research Report
Design of Dual Imaging Probes for Magnetic Resonance and Luminescence via Self-assembly of Lanthanide and Thiacalixarene
| Project/Area Number |
23655060
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
IKI Nobuhiko 東北大学, 大学院・環境科学研究科, 准教授 (50282108)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHINO Hitoshi 東北大学, 大学院・環境科学研究科, 教授 (20124620)
TAKAHASHI Toru 福井大学, 大学院・工学研究科, 講師 (30361166)
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| Project Period (FY) |
2011 – 2012
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| Keywords | イメージングプローブ / 発光イメージング / 磁気共鳴イメージング / ランタニド / チアカリックスアレーン |
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| Research Abstract |
The study is aimed at a developing dual imaging probe (DIP) for magnetic resonance imaging (MRI) and luminescence imaging to enhance the sensitivity and resolution of the current imaging techniques. Here we used thiacalixarene as a clustering ligand for multi-lanthanide core enabling both magnetic relaxation and luminescence. We have successfully elucidated that the multi-nuclear complex fulfill prerequisites for DIP such as (1) formation of single species, (2) high kinetic stability, (3) relaxivity, and(4) luminescence functions.
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