2012 Fiscal Year Final Research Report
Development of Stereospecific Cross-Coupling Reactions Using Chiral a-Branched Organometallic Reagents
| Project/Area Number |
23655082
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 結合形成 / 立体化学 / 遷移金属触媒 / 有機ホウ素化合物 / 立体特異的 / 立体反転 / 立体保持 |
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| Research Abstract |
An efficient catalyst system was established for Suzuki-Miyaura coupling of branched alkylboron reagents bearing a nitrogen functional group at the a-position. Stereochemical course of the reaction was switchable by additives. The carbon-carbon bond formation took place with inversion of configuration, when the reaction was carried out with phenol. In contrast, zirconium alkoxide mediated the reaction with retention of configuration. Two enantiomers of optically active nitrogen-containing organic compounds could be synthesized effectively by this method.
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