2012 Fiscal Year Final Research Report
Synthesis and Application of Unnatural Chiral Amino acids and Peptides
| Project/Area Number |
23655086
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 不斉合成・反応 / 非天然型キラリティー / アミノ酸 / ペプチド / 面不斉 / ケイ素不斉 / 不斉合成 / 立体化学挙動 |
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| Research Abstract |
To develop the novel field of amino acid chemistry, we focused on the synthesis of chiral amino acids and peptides having dynamic chirality or a silicon stereocenter. We accomplished the synthesis of dynamic planar chiral amino acids and peptides having an orthocyclophane skeleton. Furthermore, we successfully developed a catalytic enantioselective approach to chiral alkenylhydrosilanes, which are potential chiral building blocks for chiral amino acids having a silicon stereocenter.
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Research Products
(17 results)
