2012 Fiscal Year Final Research Report
Challenge to asymmetric ester hydrolysis with artificial catalysts
| Project/Area Number |
23655087
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TOKUNAGA Makoto 九州大学, 大学院・理学研究院, 教授 (40301767)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 選択的合成 / 不斉合成 / 有機分子触媒 |
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| Research Abstract |
Asymmetric hydrolysis of alkenyl esters and simple esters have achieved with chiral quaternary ammonium salts as phase-transfer catalysts. Maximum selectivity was 95% ee for alkenyl esters and 85% ee for simple esters, respectively. In the case of alkenyl esters, enantio-differentiation was protonation step of enolates.
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[Presentation] Asymmetric Hydrolysis of Esters with Chiral Phase-transfer Catalysts2012
Author(s)
Eiji Yamamoto, Ayano Nagai, Ryota Nakamura, Katsuma Takehisa, Akiyuki Hamasaki, Tamao Ishida, Takashi Kamachi, Kazunari Yoshizawa, and Makoto Tokunaga
Organizer
The 2 nd International Conference on MEXT Project of Integrated Research on Chemical Synthesis, "Molecular Functions in Complex Systems"
Place of Presentation
名古屋
Year and Date
2012-12-11
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[Presentation] Asymmetric Base Hydrolysis of Esters Catalyzed by Chiral Quaternary Ammonium Salts (Keynote)2012
Author(s)
E. Yamamoto, D. Gokuden, A. Nagai, R. Nakamura, K. Takehisa, A. Hamasaki, T. Ishida, T. Kamachi, K. Yoshizawa, M. Tokunaga
Organizer
17 th Malaysian Chemical Congress 2012 (17MCC)
Place of Presentation
Kuala Lumpur, Malaysia
Year and Date
2012-10-17
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