2012 Fiscal Year Final Research Report
Emergence of protein-like higher order structures and functions by dynamic reorganization of polypeptide side chains
| Project/Area Number |
23655099
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer chemistry
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| Research Institution | Yokohama National University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 動的共有結合 / ポリペプチド / イミン / アルデヒド / 高次構造 / CDスペクトル / 動的組換え |
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| Research Abstract |
A polypeptide to which a functional group derived from an aldehyde was introduced via imine bond was prepared by the reaction of the aldehyde with amino groups of poly(L-lysine) having a small amount of hydrophilic side chains. The polypeptide was dissolved in methanol along with aldehydes with various functional groups, and shuffling of side chain functional groups based on dynamic exchange between imine and aldehyde was observed. Higher-order structure of the polypeptide was found to be changed with the side-chain shuffling.
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