2012 Fiscal Year Final Research Report
Synthesis of amphiphilic polymers exhibiting liquid crystallinity at room temperature and their self-assembling in water
| Project/Area Number |
23655107
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer chemistry
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| Research Institution | Kansai University |
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Principal Investigator |
MIYATA Takashi 関西大学, 化学生命工学部, 教授 (50239414)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 液晶高分子 / 両親媒性高分子 / 自己集合 / 高分子ミセル / メソゲン基 / 臨界ミセル濃度 / DDS / 相転移 |
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| Research Abstract |
Novel amphiphilic liquid crystalline polymers (LCP-g-PEGs) exhibiting phase transition at body temperature were synthesized by introducing both hydrophobic mesogenic groups and hydrophilic PEG chains onto a polysiloxane main chain using hydrosilylation reaction. Self-assembly of LCP-g-PEG in an aqueous solution resulted in the micelle formation by hydrophobic interaction. Hydrophobic model drugs such as pyrene and fluorescein were loaded into the LCP-g-PEG micelles and their temperature-responsive drug release was investigated. The drug release from LCP-g-PEG micelles was enhanced above the phase transition temperature of LCP-g-PEG. The LCP-g-PEG micelles have potential applications as smart drug carriers for drug delivery systems.
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