2013 Fiscal Year Final Research Report
Construction of Coordination-Driven Metallopeptide Foldamers
| Project/Area Number |
23655118
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional materials chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TASHIRO Shohei 東京大学, 理学(系)研究科(研究院), 助教 (80420230)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 超分子化学 / 自己組織化 / 錯体化学 / ペプチド / 多核金属錯体 |
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| Research Abstract |
Polypeptides, which are one of the typical biopolymers, show excellent molecular functions such as molecular recognitions and catalytic reactions based on the elaborate folding structures. In this research, we aimed at the construction of peptide-based functional molecules with unique structural diversity and functions by designing "metallopeptide foldamers" that can fold into various secondary structures through metal coordination as substitute for hydrogen bonding. Indeed, we revealed that a series of an artificial oxime-peptide which was newly synthesized by us formed several mononuclear and multinuclear metal complexes with unique secondary structures through metal coordination.
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Research Products
(13 results)
