2013 Fiscal Year Final Research Report
Development of supramolecular systems for the regulation of bio-supramolecular functions
| Project/Area Number |
23655136
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional materials chemistry
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
YUAN De-Qi 神戸学院大学, 薬学部, 教授 (70304962)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 超分子化学 / 人工レセプター / 分子認識 / cucurbit[n]uril |
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| Research Abstract |
An convenient method has been established for the synthesis and purification of cucurbit[7]uril. The binding behavior of cucurbit[7]uril and a large variety of guest compounds including acetylcholine and their analogs has been investigated. Cucurbit[7]uril binds acetylcholine with very strong affinity that competing natural acetylcholine receptors. It was clarified that cucurbit[7]uril binds the onium ions deep in its cavity to form very stable inclusion complexes. Cucurbit[7]uril also forms stable inclusion complexes with neutral guests of the similar shape and size to that of onium ions but confronts much higher energy barriers.
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