2013 Fiscal Year Final Research Report
Develppment of Non-tocic and Luminescent Nanoparticles for Bioimaging
| Project/Area Number |
23655138
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional materials chemistry
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
SHIRAHATA Naoto 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 独立研究者 (80421428)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生体ラベリング / 蛍光標識 / リン光標識 / ドラッグデリバリー / シリコン / ゲルマニウム / 蒼鉛 / ナノ粒子 |
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| Research Abstract |
We successfully synthesized luminescent and non-toxic nanoparticles for precise monitoring ofbiomolecular interaction events. The tuning range of emission covers over 300-2000 nm of NUV-VIS-NIR region by choosing the nanoparticles in which the structures (size, phase, composition) are carefully controlled. Control over the nanoparticle surfaces provides the water solubility, and subsequently leads to the success of in-vivo andin-vitro biomonitoring by taking advantage of luminescence from the nanoparticles.All of nanoparticles are non-toxic.
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[Journal Article] Highly Fluorescent Silica-Coated Bismuth Doped Aluminosilicate Nanoparticles for Near Infrared Bioimaging2011
Author(s)
H. Sun, J. Yang, M. Fujii, Y. Sakka, Y. Zhu, T. Asahara, N. Shirahata, M. Ii, Z. Bai, J. Li, H. Gao
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Journal Title
Small
Volume: 7
Pages: 199-203
DOI
Peer Reviewed
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