2012 Fiscal Year Final Research Report
Creation of Artificial Biocatalysts Capable of Catalyzing C-C Bond Formation
| Project/Area Number |
23655157
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Okayama University |
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Principal Investigator |
EMA Tadashi 岡山大学, 大学院・自然科学研究科, 教授 (20263626)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 酵素反応 / 生体触媒 / 合成化学 / 不斉合成 |
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| Research Abstract |
Articificial enzymes (lipases) bearing N-heterocyclic carbene (NHC) were created and used as a catalyst for the enantioselective C-C bond formation. NHC was linked to a mutated cystein residue or the active site. The articificial enzymes catalyzed the benzoin reaction with low enantioselectivity
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