2012 Fiscal Year Final Research Report
Challenge to cancer therapy and visualization with magnetic nanoparticles by pulsing alternating-current magnetic fields
| Project/Area Number |
23655204
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic industrial materials
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 交流磁場 / 磁性ナノ粒子 / がんの治療 / ハイパーサーミア / パルス状交流磁場 / ヒーラ細胞(ヒト子宮頸部がん細胞) / ナノ複合体 / 音波の発生と検出 |
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| Research Abstract |
Hyperthermia is a cancer treatment modality that destroys tumors by elevating the temperature of the cancerous tissue to around 43 °C. Then, we synthesized the magnetic nanoparticles like Fe_3O_4, γ-Fe_2O_3and α-Fe_2O_3with different sizes and shapes and nanocomposites with core-shell structures like Au-Fe_3O_4and Fe_3O_4-TiO_2. We studied the cancer cell killing effects under three distinct conditions, a) only CW or pulsed alternating-current (AC) magnetic-field induction, b) only photoirradiation and c) combined CW or pulsed AC magnetic-field induction and photoirradiation conditions. For HeLa cancer cells adopted as a model to investigate the thermal-photocatalytic cancer cell killing efficiency of as-synthesized nanomaterials, almost100% cancer cells were destructed under combined (CW or pulsed) AC magnetic-field induction and photoirradiation conditions. We got fruitful information on the sound-waves detection induced by pulsed AC magnetic-fields for aqueous solution including magnetic nanoparticles.
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