2012 Fiscal Year Final Research Report
Development ofporous multi-layer biomaterial and basic study on regeneration of cartilage-bone multi-layer tissue
| Project/Area Number |
23656090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Kyushu University |
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Principal Investigator |
TODO Mitsugu 九州大学, 応用力学研究所, 准教授 (80274538)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体材料 / 再生医療 / 整形外科 |
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| Research Abstract |
The primary aim of this study was to develop multi-layer scaffolds having biomechanical compatibility with natural cartilage-bone layered tissue in order to apply to regenerative medicine for large scale injuries of joints. Fundamental fabrication process for regenerated artificial bone tissue was also tried to be established. Novel bioabsorbable multi-layer porous materials imitating the mechanical properties of cartilage-bone layered tissue was successfully developed by using biodegradable polymers such as PCL and PLLA with bioceramic HA. It was found that the compressive properties of the layered scaffolds are very similar to those of natural layered tissues. Regenerated artificial bone tissues have also developed by culturing mesenchymal stem cells with organic/inorganic composite scaffold for a certain period.
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