2012 Fiscal Year Final Research Report
Developmentofcontrol for amyloid toxicity by novel Screening system
| Project/Area Number |
23656525
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Okayama University (2012)
Osaka University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Keywords | メンブレン・ストレスバイオテクノロジー / LIPOzyme / 生体膜 / 人工酵素 / バイオリアクター |
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| Research Abstract |
Amyloid fibrils is generally propagated on biomembranes to induce the cell toxicity. Meanwhile, there is no methodology to stop the aforesaid event. In this study, we challenged the development of toxicity control of amyloid fibrils using liposomes. It has been demonstrated that liposome library could give (i) the adequate liposome with lipid composition advantageous for a control of toxicity of amyloid fibrils and (ii) LIPOzyme with the function to promote the inhibitory of fibril formation or disaggregatiojn of fibrils. Those results have implied a possibility on the development of detoxic process of amyloid fibrils by using liposomes.
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