Development of Cell Irradiation System aimed by 3D-CT

2013 Fiscal Year Final Research Report

• Project/Area Number: 23656583
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nuclear engineering
• Research Institution: Tohoku University
• Principal Investigator: SHIGEO Matsuyama 東北大学, 工学(系)研究科(研究院), 准教授 (70219525)
• Co-Investigator(Kenkyū-buntansha): ISHII Keizo 東北大学, 大学院・工学研究科, リサーチプロフェッサー (00134065)
• Project Period (FY): 2011 – 2013
• Keywords: 3D-CT / 細胞照射 / マイクロビーム

Research Abstract

The spatial resolution the Tohoku microbeam formation system achieved 1 micron or less, but spatial resolution of the micron CT was confined to around 5 microns because beam intensity was not enough in the CT experiments. In order to improve beam intensity, energy resolution of the Dynamitron accelerator was improved. Beam currents of 250 pA was achieved with a spatial resolution of 1 micron meter.
Sample stage was improved in order to irradiate cells aimed by 3D-CT measurement. This set-up enabled to irradiate cells after 3D-CT measurement.

Research Products

• [Journal Article] Improvement and recent applications of the Tohoku microbeam system (2014)
  • Author(s): S. Matsuyama, K. Ishii, K. Watanabe, A. Terakawa, Y. Kikuchi, M. Fujiwara, H. Sugai, M. Karahashi, Y. Nozawa, S. Yamauchi, M. Fujisawa, M. Ishiya, T. Nagaya, R. Ortega, A. Carmona, S. Roudeau
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 318 Pages: 32-36
  • URL: http://www.sciencedirect.com/science/journal/01675087
  • Peer Reviewed
• [Journal Article] Concentration of Cs in plants and water resulting from radioactive pollution (2014)
  • Author(s): A. Ishizaki, K. Ishii, S. Matsuyama, F. Fujishiro, H. Arai, N. Osada, H. Sugai, S. Koshio, S. Yamauchi, K. Kusano, Y. Nozawa, M. Karahashi, S. Oshikawa, K. Kikuchi, K. Watanabe, S. Itoh, K. Kasahara, S. Toyama, Y. Suzuki
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 318 Pages: 105-108
  • URL: http://www.sciencedirect.com/science/journal/01675087
  • Peer Reviewed
• [Journal Article] Micro-PIXE evaluation of radioactive cesium transfer in contaminated soil samples (2014)
  • Author(s): F. Fujishiro, K. Ishii, S. Matsuyama, H. Arai, A. Ishizaki, N. Osada, H. Sugai, K. Kusano, Y. Nozawa, S. Yamauchi, M. Karahashi, S. Oshikawa, K. Kikuchi, S. Koshio, K. Watanabe, Y. Suzuki
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 318 Pages: 99-101
  • URL: http://www.sciencedirect.com/science/journal/01675087
  • Peer Reviewed
• [Journal Article] PIXE analyses of cesium in rice grains (2014)
  • Author(s): Hiroyuki Sugai, Keizo Ishii, Shigeo Matsuyama, Atsuki Terakawa, Yohei Kikuchi, Hiroaki Takahashi, Azusa Ishizaki, Fumito Fujishiro, Hirotsugu Arai, Naoyuki Osada, Masahiro Karahashi, Yuichiro Nozawa, Shosei Yamauchi, Kosuke Kikuchi, Shigeki Koshio, Koji Watanabe
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 318 Pages: 191-193
  • URL: http://www.sciencedirect.com/science/journal/01675087
  • Peer Reviewed
• [Journal Article] Remediation of plants contaminated with cesium by aqueous cleaning (2014)
  • Author(s): N. Osada, K. Ishii, S. Matsuyama, H. Sugai, K. Kusano, Y. Nozawa, S. Yamauchi, M. Karahashi, S. Oshikawa, K. Kikuchi, S. Koshio, K. Watanabe, S. Itoh, Y. Suzuki, A. Terakawa, Y. Kikuchi, F. Fujishiro, A. Ishizaki, H. Arai
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 318 Pages: 102-104
  • URL: http://www.sciencedirect.com/science/journal/01675087
  • Peer Reviewed
• [Journal Article] Reducing logistical barriers to radioactive soil remediation after the Fukushima No. 1 nuclear power plant accident (2014)
  • Author(s): K. Ishii, A. Terakawa, S. Matsuyama, Y. Kikuchi, F. Fujishiro, A. Ishizaki, N. Osada, H. Arai, H. Sugai, H. Takahashi, K. Nagakubo, T. Sakurada, H. Yamazaki, S. Kim
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 318 Pages: 70-75
  • URL: http://www.sciencedirect.com/science/journal/01675087
  • Peer Reviewed
• [Journal Article] Improvement of the energy stability of the Tohoku Dynamitron accelerator for microbeam and nanobeam applications (2013)
  • Author(s): S. Matsuyama, M. Fujisawa, T. Nagaya, K. Ishii, A. Terakawa, Y. Kikuchi, M. Fujiwara, K. Watanabe, M. Karahashi, Y. Nozawa, S. Yamauchi and M. Ishiya
  • Journal Title: International Journal of PIXE Volume: Vol.23, Nos.1&2 Pages: 69-75
  • URL: http://www.worldscientific.com/loi/ijpixe
  • Peer Reviewed
• [Journal Article] IMPROVEMENT OF THE DETECTION EFFICIENCY OF THE IN-AIR SUBMILLI- PIXE CAMERA FOR BIOLOGICAL APPLICATIONS (2012)
  • Author(s): H. SUGAI, K. FUJIKI, K. ISHII, S. MATSUYAMA, A. TERAKAWA, Y. KIKUCHI, M. FUJIWARA, Y. HATORI, N. HAMADA, Y. ITOH, S. HIRAISHI, Y. MIURA and A. FUKAYA, H. YAMAZAKI and T. TADA, E. SAKURAI
  • Journal Title: International Journal of PIXE Volume: Vol.22, Nos.1&2 Pages: 191-193
  • URL: http://www.worldscientific.com/loi/ijpixe
  • Peer Reviewed
• [Journal Article] ANALYSIS OF TRACE ELEMENTS IN PREAND POST-NATAL TOOTH ENAMEL USING MICRO-PIXE (2012)
  • Author(s): K. IGARI, A. TAKAHASHI, N. GOTOH and K. SASAKI, K. ISHII, S. MATSUYAMA, H. SUGAI, K. FUJIKI, Y. HATORI, Y. ITOU, S. HIRAISHI and Y. MIURA, H. YAMAZAKI
  • Journal Title: International Journal of PIXE Volume: Vol.22, Nos.1&2 Pages: 101-106
  • URL: http://www.worldscientific.com/loi/ijpixe
  • Peer Reviewed
• [Journal Article] DEVELOPMENT OF μ-PIXE/RBS/SEM SYSTEM FOR CORROSION LAYER ANALYSIS OF STEEL (2011)
  • Author(s): S. MATSUYAMA, K. ISHII, M. FUJIWARA, Y. KIKUCHI, H. SUGAI, K. FUJIKI, Y. HATORI, N. HAMADA, Y. ITO, S. HIRAISHI, Y. MIURA, A. FUKAYA, S. TANNO, H. ABE, Y. WATANABE and H. YAMAZAKI
  • Journal Title: International Journal of PIXE Volume: vol.21 Nos3&4 Pages: 87-93
  • URL: http://www.worldscientific.com/loi/ijpixe
  • Peer Reviewed
• [Journal Article] Microbeam analysis of individual particles in indoor working environment (2011)
  • Author(s): S. Matsuyama, G. Catella, K. Ishii, A. Terakawa, Y. Kikuchi, Y. Kawamura, S. Ohkura, M. Fujikawa, N. Hamada, K. Fujiki, Y. Hatori, Y. Ito, H. Yamazaki, Y. Hashimoto, M. Zitnik, P. Pelicon and N. Grlj
  • Journal Title: X-Ray Spectrom Volume: 40 Pages: 172-175
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4539
  • Peer Reviewed
• [Journal Article] In vivo 3D imaging of Drosophila melanogaster using PIXE-micron-CT (2011)
  • Author(s): S. Ohkura, K. Ishii, S. Matsuyama, A. Terakawa, Y. Kikuchi, Y. Kawamura, G. Catella, Y. Hashimoto, M. Fujikawa, N. Hamada, K. Fujiki, E. Hatori and H. Yamazaki
  • Journal Title: X-Ray Spectrom Volume: 40 Pages: 191-193
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4539
  • Peer Reviewed
• [Journal Article] PIXE analysis of amurine solid tumor treated with proton therapy combined with cisplatin (2011)
  • Author(s): A. Terakawa, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Ito, A. Tagawa, S. Yasunaga, T. Kawamura, Y. Takahashi, Y. Hatori, N. Hamada, K. Fujiki, N. Ito, S. Wada, Y. Funaki and K. Sera
  • Journal Title: X-Ray Spectrom Volume: 40 Pages: 198-201
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4539
  • Peer Reviewed
• [Presentation] ナノビーム分析システムの開発 (2014)
  • Author(s): 松山成男, 石井慶造, 寺川貴樹, 渡部浩司, 小塩成基, 菊池航介, 押川峻, 藤澤政則, 石屋大志, 永谷隆男
  • Organizer: 日本原子力学会「2014年春の年会」
  • Place of Presentation: 東京都市大学世田谷キャンパス
  • Year and Date: 20140326-28
• [Presentation] ナノビーム形成のための東北大学ダイナミトロン加速器の高圧発生回路の安定化 (2013)
  • Author(s): 松山成男, 石井慶造, 寺川貴樹, 藤原充啓, 渡部浩司, 菊池浩介, 小塩成基, 押川駿, 遠山翔, 藤澤政則, 石屋大志, 永谷隆男
  • Organizer: 第29回PIXE シンポジウム プログラム
  • Place of Presentation: 福井県若狭湾エネルギー研究センター
  • Year and Date: 20131113-15
• [Presentation] ナノビーム分析の実現に向けたマイクロビームシステムの改良 (2013)
  • Author(s): 渡部浩司, 松山成男, 石井慶造, 寺川貴樹, 藤原充啓, 小塩成基, 押川峻, 藤澤政則, 石屋大志, 永谷隆男
  • Organizer: 第29回PIXE シンポジウム プログラム
  • Place of Presentation: 福井県若狭湾エネルギー研究センター
  • Year and Date: 20131113-15
• [Presentation] 有害金属元素 に曝露されたヒト肺上皮細胞の 3D -PIXE-μ-CT 分析 (2013)
  • Author(s): 鈴木優生, 石井慶造, 松山成男, Richard Ortega, A.Carmona, R.Roudeau, 押川峻, 小塩成基, 菊池航介, 藤田明希穂, 渡部浩司
  • Organizer: 第29回PIXE シンポジウム プログラム
  • Place of Presentation: 福井県若狭湾エネルギー研究センター
  • Year and Date: 20131113-15
• [Presentation] PIXE分析を用いた生体試料中の3 次元元素分布画像取得法の開発 (2013)
  • Author(s): 松山哲生, 石井慶造, 寺川貴樹, 松山成男, 押川峻, 菊池航介, 小塩成基, 藤田明希穂, 鈴木優生, 渡邉浩司, 遠山翔, 伊藤駿, 平方遥子
  • Organizer: 第29回PIXE シンポジウム プログラム
  • Place of Presentation: 福井県若狭湾エネルギー研究センター
  • Year and Date: 20131113-15
• [Presentation] 稲穂内部のCs および Rb のマイクロ PIXE 分析 (2013)
  • Author(s): 小塩成基, 菅井裕之, 石井慶造, 松山成男, 寺川貴樹, 伊藤駿, 鈴木優生, 松山哲男, 渡部浩司
  • Organizer: 第29回PIXE シンポジウム プログラム
  • Place of Presentation: 福井県若狭湾エネルギー研究センター
  • Year and Date: 20131113-15
• [Presentation] PIXE 分析用トレーサーへの量子ドットの応用に関する研究 (2013)
  • Author(s): 石井慶造, 寺川貴樹, 松山成男, 菊池洋平, 松山哲生
  • Organizer: 日本原子力学会「2013年秋の大会」
  • Place of Presentation: 八戸工業大学
  • Year and Date: 20130903-05
• [Presentation] 造影剤を用いたショウジョウバエのX 線動画像撮影法の開発 (2013)
  • Author(s): 小塩成基, 石井慶造, 松山成男, 寺川貴樹, 菊池洋平, 能澤雄一郎, 遠山翔
  • Organizer: 日本原子力学会「2013年秋の大会」
  • Place of Presentation: 八戸工業大学
  • Year and Date: 20130903-05
• [Presentation] 酸化コバルトに曝露されたヒト肺上皮細胞の3D-PIXE-μ-CT 分析 (2013)
  • Author(s): 石井慶造, 松山成男, 鈴木優生
  • Organizer: 日本原子力学会「2013年秋の大会」
  • Place of Presentation: 八戸工業大学
  • Year and Date: 20130903-05
• [Presentation] 東北大学ダイナミトロン加速器の電圧安定性向上 (2013)
  • Author(s): 松山成男, 石井慶造, 寺川貴樹, 菊池洋平, 渡部浩司, 菊池航介, 小塩成基, 押川峻, 遠山翔, 唐橋昌宏, 能澤雄一郎, 山内祥聖, 藤澤政則, 石屋大志, 永谷隆男
  • Organizer: 日本原子力学会「2013年秋の大会」
  • Place of Presentation: 八戸工業大学
  • Year and Date: 20130903-05