2012 Fiscal Year Final Research Report
Occupying the space :A new phenomenon in cell attachment,and the elucidation of molecular mechanism
| Project/Area Number |
23657049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞接着 / 場所取り |
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| Research Abstract |
When suspended adherent monolayer mammalian cells are plated onto a culture dish,the cells disperse almost uniformly as single cells and attach to the surface of the plastic cell cultureware. Subsequently,the cells grow in the shape of a pavement,and finally the cell growth and motility arrest by“contactinhibition”.This phenomenon is known for more than half acentury.In this study,I found that a new phenomenon called“occupying the space” existed for the first time in this process to disperse the cells uniformly.Furthermore,I considered the generality of this finding.
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