2012 Fiscal Year Final Research Report
Establishmentof tools regulating mitophagyby chemical biology
| Project/Area Number |
23657090
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
OKAMOTO Koji 大阪大学, 大学院・生命機能研究科, 特任准教授 (40455217)
|
|---|
| Research Collaborator |
OKAMOTO Noriko 大阪大学, 大学院・生命機能研究科, 特任研究員 (90568750)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ミトコンドリア / オートファジー / 品質管理 / オルガネラ膜動態 |
|---|
| Research Abstract |
In this study, we focused on mitophagy, one of the mitochondrial quality control systems that selectively degrades the energy-converting organelles governing cell life and death via autophagy. Particularly, using budding yeast as a model organism, we sought to establish the molecular bases and regulatory tools that artificially suppress or facilitate mitophagy.
|
-
-
-
-
[Journal Article] Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.2012
Author(s)
Kondo-Okamoto, N., Noda, N.N., Suzuki, S.W., Nakatogawa, H., Takahashi, I., Matsunami, M., Hashimoto, A., Inagaki, F., Ohsumi, Y., Okamoto, K
-
Journal Title
J. Biol. Chem
Volume: 287
Pages: 10631-10638
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
