2012 Fiscal Year Final Research Report
Development of Scanning Optical Resonance Cavity RamanMicroscope and its Application to the Monitoring the Response of Cell under Mechanical Stimuli
| Project/Area Number |
23657108
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
YUI Hiroharu 東京理科大学, 理学部, 准教授 (20313017)
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| Co-Investigator(Renkei-kenkyūsha) |
OTSUKA Hidenori 東京理科大学, 理学部, 准教授 (00344193)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 光共振器 / ラマン散乱 / 顕微鏡 / 細胞 / 力学応答 |
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| Research Abstract |
To obtain interface-selective Raman signals from a single living cell under mechanical stimuli, we have developed a scanning optical resonance cavity Raman microscope. To change the probe to one with a non-contact manner, we applied an optical pressure by laser-beam irradiation for probing the mechanical response of a single living cell at optional points utilizing a microscope. The newly developed original microscope enables us to measure the viscoelasticity of a single cell with a non-contact manner. In addition, resonant Raman signals were detected under the same microscope, which will provide information on the molecular origin of viscoelasticity in a single living cell
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[Remarks] 森作俊紀、蟻田彩子、由井宏治(社)日本分析化学会第60 年会 若手講演賞受賞「レーザー誘起界面変位顕微鏡の開発と単一生細胞における生体膜力学物性の非接触計測への応用」 2011 年 9 月 14 日
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[Remarks] 蟻田彩子、五十嵐有輔、森作俊紀、由井宏治(社)日本化学会 第63回コロイド及び界面化学討論会 ポスター賞受賞「レーザー誘起界面変位顕微鏡の開発と単一生細胞膜張力の非接触測定」 2011 年 9 月 8 日
