2013 Fiscal Year Final Research Report

Characterization of the ubiquitin code

Research Project

Project/Area Number	23657112
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Molecular biology
Research Institution	National Institute of Health Sciences (2012-2013) The University of Tokyo (2011)
Principal Investigator	OHTAKE Fumiaki 国立医薬品食品衛生研究所, 毒性部, 主任研究官 (60447373)
Project Period (FY)	2011 – 2012
Keywords	ユビキチン / 翻訳後修飾 / 蛋白質
Research Abstract	Post-translational modifications (PTMs) govern many aspects of biological systems. Ubiquitylation is a versatile PTM whose functional diversity has not been fully understood. In this study, we investigated a possibility that ubiquitin, itself a source of PTM, is functionally regulated by another PTM. Our research identified ubiquitin phosphorylation sites from cellular ubiquitin conjugated to substrates.

(1 results)