2013 Fiscal Year Final Research Report
Characterization of the ubiquitin code
| Project/Area Number |
23657112
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | National Institute of Health Sciences (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
OHTAKE Fumiaki 国立医薬品食品衛生研究所, 毒性部, 主任研究官 (60447373)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ユビキチン / 翻訳後修飾 / 蛋白質 |
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| Research Abstract |
Post-translational modifications (PTMs) govern many aspects of biological systems. Ubiquitylation is a versatile PTM whose functional diversity has not been fully understood. In this study, we investigated a possibility that ubiquitin, itself a source of PTM, is functionally regulated by another PTM. Our research identified ubiquitin phosphorylation sites from cellular ubiquitin conjugated to substrates.
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