2012 Fiscal Year Final Research Report
Transcriptional regulation in multinucleated cells
| Project/Area Number |
23657113
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転写制御 |
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| Research Abstract |
The neuromuscular junction (NMJ) is an essential synapse between a motor neuron and skeletal muscle. In mammals, the NMJ forms in the central region of each myotube, a multinucleated fibrous cell, and it is widely accepted that this requires the centrally localized, postsynaptic nuclei-specific expression of genes encoding NMJ proteins. The muscle-specific kinase MuSK, which governs the NMJ formation in skeletal muscle, plays an essential role in the post-synaptic transcriptional regulation. However, expression of the NMJ protein Dok-7 is not under the MuSK-dependent regulation. As an initial step toward understanding the regulatory mechanisms, we studied transcriptional regulation of the dok-7 gene.
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[Journal Article] A Mutation causes MuSK reduced sensitivity to agrin and congenital myasthenia.2013
Author(s)
Ammar AB, Soltanzadeh P, Bauche S, Richard P, Goillot E, Herbst R, Gaudon K, Huze C, Schaeffer L, Yamanashi Y, Higuchi O, Taly A, Koenig J, Leroy J-P, Hentati F, Najmabadi H, Kahrizi K, Ilkhani M, Fardeau M, Eymard B, Hantai D.
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Journal Title
PLoS One
Volume: 8
Pages: e53826
DOI
Peer Reviewed
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