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2012 Fiscal Year Final Research Report

Reactions required for eukaryotic mismatch repair to function in the context of chromatin

Research Project

  • PDF
Project/Area Number 23657114
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionOsaka University

Principal Investigator

TAKAHASHI Tatsuro  大阪大学, 大学院・理学研究科, 助教 (50452420)

Project Period (FY) 2011 – 2012
KeywordsDNA 損傷・修復 / クロマチン
Research Abstract

The mismatch repair system corrects replication errors to protect genomic information from mutations. The mismatch repair system functions after DNA synthesis, at the time when chromatin reassembly takes place. However, the reactions required for mismatch repair to function in the context of chromatin remain elusive. We sought factors that are involved in the mismatch repair reaction in the chromatin context, and identified several candidate factors. Our study will contribute to further understanding of the eukaryotic mismatch repair reaction.

  • Research Products

    (2 results)

All 2012

All Presentation (2 results)

  • [Presentation] Coupling of DNA mismatch repair and chromatin replication2012

    • Author(s)
      高橋 達郎、滝 佳菜恵、照井 利輝、長尾 恒治、中川 拓郎、小布施 力史、升方 久夫
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      20121210-14
  • [Presentation] Inhibition of chromatin assembly by the mismatch repair system2012

    • Author(s)
      高橋 達郎
    • Organizer
      第二回 日仏がんワークショップ
    • Place of Presentation
      徳島県鳴門市
    • Year and Date
      20121129-1201

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Published: 2014-09-25  

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