2012 Fiscal Year Final Research Report
Molecular mechanism of cancer induction -failure in regulation of guidance signalling
| Project/Area Number |
23657127
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Kyoto University |
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Principal Investigator |
OINUMA Izumi 京都大学, 大学院・生命科学研究科, 助教 (40452297)
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| Project Period (FY) |
2011 – 2012
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| Keywords | R-Ras / 低分子量 G タンパク質 / ガイダンス因子 / アクチン / セマフォリン |
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| Research Abstract |
In this project, we revealed the signal transductions of a small GTPase R-Ras. In cancer cells, R-Ras activity is reported to be increased by miss-regulation of guidance factors. Through biochemical research, we identified Lamellipodin as a novel effector for R-Ras. We also confirmed that the R-Ras-Lamellipodin pathway is utilized by the guidance factor signaling.
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