Challenge to dogma in autophagy

2012 Fiscal Year Final Research Report

• Project/Area Number: 23657129
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: YOSHIMORI Tamotsu 大阪大学, 大学院・生命機能研究科, 教授 (60191649)
• Project Period (FY): 2011 – 2012
• Keywords: オートファジー / 標的認識 / Atg

Research Abstract

Autophagy is intracellular bulk degradation system. While recent progress in autophagy field has expanded our knowledge of the process, there are some dogma, which are widely believed but examined well. Here, we analyzed carefully one of them, a believed model for target recognition in selective autophagy. We showed that interaction between adopter proteins and LC3 is not enough to explain the recognition and there is a case that target itself is not recognized.

Research Products

• [Journal Article] Autophagy Plays a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes (2013)
  • Author(s): Murase D, Hachiya A, Takano K, Hicks R, Visscher MO, Kitahara T, Hase T, Takema Y, Yoshimori T
  • Journal Title: J Invest Dermatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Autophagosomes form at ER-mitochondria contact sites (2013)
  • Author(s): Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A*, Yoshimori T*
  • Journal Title: Nature Volume: 495(7441) Pages: 389-393
  • Peer Reviewed
• [Journal Article] Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia (2013)
  • Author(s): Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T, Saito S
  • Journal Title: Autophagy Volume: 9(3) Pages: 303-316
  • Peer Reviewed
• [Journal Article] Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis (2013)
  • Author(s): Fukuda T, Matsumura T, Ato M, Hamasaki M, Nishiuchi Y, Murakami Y, Maeda Y, Yoshimori T, Matsumoto S, Kobayashi K, Kinoshita T, Morita YS
  • Journal Title: Mbio Volume: 4(1) Pages: e00472-12
  • Peer Reviewed
• [Journal Article] Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking (2012)
  • Author(s): Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU
  • Journal Title: J Cell Sci Volume: 125(Pt 20) Pages: 4740-4750
  • Peer Reviewed
• [Journal Article] Autophagy creates a CTL epitope that mimics tumor-associated antigens (2012)
  • Author(s): Demachi-Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K
  • Journal Title: PLoS One Volume: 7(10) Pages: e47126
  • Peer Reviewed
• [Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma (2012)
  • Author(s): Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
  • Journal Title: Int J Cancer Volume: 131(3) Pages: 548-557
  • Peer Reviewed
• [Journal Article] Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection (2012)
  • Author(s): Matsumoto Y, Hayashi Y, Omori H, Honda T, Daito T, Horie M, Ikuta K, Fujino K, Nakamura S, Schneider U, Chase G, Yoshimori T, Schwemmle M, Tomonaga K
  • Journal Title: Cell Host Microbe Volume: 11(5) Pages: 492-503
  • Peer Reviewed
• [Journal Article] Jo EK.Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action (2012)
  • Author(s): Kim JJ, Lee HM, Shin DM, Kim W, Yuk JM, Jin HS, Lee SH, Cha GH, Kim JM, Lee ZW, Shin SJ, Yoo H, Park YK, Park JB, Chung J, Yoshimori T
  • Journal Title: Cell Host Microbe Volume: 11(5) Pages: 457-468
  • Peer Reviewed
• [Journal Article] Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans (2012)
  • Author(s): Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar
  • Journal Title: Gastroenterology Volume: 142(5) Pages: 1160-1171
  • Peer Reviewed
• [Journal Article] Autophagy guards against Cisplatin-induced acute kidney injury (2012)
  • Author(s): Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H*, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y*, Rakugi H
  • Journal Title: Am J Pathol Volume: 180(2) Pages: 517-525
  • Peer Reviewed
• [Journal Article] Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex (2011)
  • Author(s): Ishibashi K, Fujita N, Kanno E, Omori H, Yoshimori T, Itoh T, Fukuda M*
  • Journal Title: Autophagy Volume: 7(12) Pages: 1500-1513
  • Peer Reviewed
• [Journal Article] Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus (2011)
  • Author(s): Taguwa S, Kambara H, Fujita N, Noda T, Yoshimori T, Koike K, Moriishi K, Matsuura Y*
  • Journal Title: J Virol Volume: 85(24) Pages: 13185-13194
  • Peer Reviewed
• [Journal Article] A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery (2011)
  • Author(s): Katayama H, Kogure T, Mizushima N, Yoshimori T, Miyawaki A*
  • Journal Title: Chem Biol Volume: 18(8) Pages: 1042-1052
  • Peer Reviewed
• [Journal Article] The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella (2011)
  • Author(s): Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T*
  • Journal Title: Mol Biol Cell Volume: 22 Pages: 2290-2300
  • Peer Reviewed
• [Journal Article] Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation (2011)
  • Author(s): Tachiyama R, Ishikawa D, Matsumoto M, Nakayama KI, Yoshimori T, Yokota S, Himeno M, Tanaka Y, Fujita H*
  • Journal Title: Genes Cells Volume: 16 Pages: 448-466
  • Peer Reviewed
• [Presentation] Mechanistic Insights into Autophagy against Bacteria Invading Host Cells (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Cambridge Immunology Forum 2012
  • Place of Presentation: Cambridge, UK
  • Year and Date: 2012-09-20
• [Presentation] Insights into Membrane Dynamics in Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on Autophagy in Health and Disease in Tel Aviv
  • Place of Presentation: Israel
  • Year and Date: 2011-10-31
• [Book] Q&A / 哺乳類におけるオートファジー関連因子オートファジー 生命をささえる細胞の自己分解システム水島昇・吉森保 編 (2012)
  • Author(s): 吉森 保
  • Total Pages: 48-66
  • Publisher: 化学同人
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/jp/achievement/010/