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2012 Fiscal Year Final Research Report

Paleogenomics on Jomon and Yayoi human remains by using next generation sequencer

Research Project

  • PDF
Project/Area Number 23657167
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical anthropology
Research InstitutionKitasato University

Principal Investigator

OOTA Hiroki  北里大学, 医学部, 准教授 (40401228)

Co-Investigator(Kenkyū-buntansha) HANIHARA Tsunehiko  北里大学, 医学部, 教授 (00180919)
ISHIDA Hajime  琉球大学, 医学部, 教授 (70145225)
KIMURA Ryosuke  琉球大学, 亜熱帯島嶼科学超域研究推進機構, 准教授 (00453712)
MANO Shuhei  統計数理研究所, 数理・推論研究系, 准教授 (20372948)
Project Period (FY) 2011 – 2012
Keywordsパーソナルゲノム / 縄文人 / 弥生人 / 次世代シークエンサー / 日本人の起源 / 沖縄 / 先島諸島 / アイヌ
Research Abstract

We successfully extracted DNAs from ancient human and animal bones that could be analyzed by next generation sequencers. The DNAs were degraded to less than 70bp and modified chemically. The extractions contained a huge amount of bacterial DNAs. Haplotype analyses strongly suggested the very close relationship between Ainu and Ryukyuan.

  • Research Products

    (20 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (16 results) Book (2 results)

  • [Journal Article] Crohn's Disease Risk Alleles on the NOD2 Locus Have Been Maintained by Natural Selection on Standing Variation2012

    • Author(s)
      S.Nakagome,S.Mano,L.Kozlowski,J.M.BuJnicki,H.Shibata,Y.Fukumaki,J.R.Kidd,K.K.Kidd,S.Kawamura,H.Oota
    • Journal Title

      Molecular Biology and Evolution

      Volume: 29 Pages: 1569-1585

    • DOI

      DOI:10.1093/molbey/mss006

    • Peer Reviewed
  • [Journal Article] Effects of anAsian-specific nonsynonymous EDARvariant on multiple dental traits2012

    • Author(s)
      J H.Park,T.Yamaguchi,C.Watanabe,A.Kawaguchi,K.Haneji,M.Takeda,Y I.Kim,Y.Tomoyasu,M.Watanabe,H.Oota,T.Hanihara,H.Ishida,K.Maki,SB.Park,R.Kimura
    • Journal Title

      Journal of Human Genetics

      Volume: 57(8) Pages: 508-514

    • DOI

      DOI:10.1038/jhg.2012.60

    • Peer Reviewed
  • [Presentation] ゲノムワイド SNPデータに基づく琉球列島の人々の集団構造2012

    • Author(s)
      佐藤丈寛、川口亮、石田肇、山口徹太郎、山本健、河村正二、中込滋樹、間野修平、埴原恒彦、太田博樹、渡辺千晶、山口今日子、木村亮介
    • Organizer
      第66回日本人類学会大会
    • Place of Presentation
      神奈川
    • Year and Date
      20121102-04
  • [Presentation] 琉球諸島と北部九州におけるクローン病の遺伝と環境の相互作用に関する人類学的考察2012

    • Author(s)
      中込滋樹、知念寛、竹山康章、Said H.S.、須田亙、木村亮介、石田肇、埴原恒彦、Kidd J.R.、Kidd K.K.、河村正 二、森田英利、服部正平、間野修平、太田博樹
    • Organizer
      第66回日本人類学会大会
    • Place of Presentation
      神奈川
    • Year and Date
      20121102-04
  • [Presentation] 現代日本人の寒冷適応能とミトコンドリアハプログループの関係について2012

    • Author(s)
      西村貴孝、本井碧、星良和、近藤隆一郎、太田博樹、綿貫茂喜
    • Organizer
      第66回日本人類学会大会
    • Place of Presentation
      神奈川
    • Year and Date
      20121102-04
  • [Presentation] ヒトとメダカ共通に観察された地域集団間の性的二型の程度の違いに関与する遺伝的多型2012

    • Author(s)
      勝村啓史、尾田正二、三谷啓志、埴原恒彦、河村正二、太田博樹
    • Organizer
      第66回日本人類学会大会
    • Place of Presentation
      神奈川
    • Year and Date
      20121102-04
  • [Presentation] 米田穣動物遺存体および化石における古代 DNA分析の新たなプレスクリーニング法2012

    • Author(s)
      覚張隆史、太田博樹、大谷進
    • Organizer
      第66回日本人類学会大会
    • Place of Presentation
      神奈川
    • Year and Date
      20121102-04
  • [Presentation] 遺伝学と生物医学における集団のラベリング/Population Descripors in Genetics andBiomedicine2012

    • Author(s)
      竹沢泰子、加藤和人、太田博樹
    • Organizer
      京都大学人文科学研究所科研基盤(S)「人種表象の日本型グローバル研究」第2回 Knowledge-科学と社会の共生産
    • Place of Presentation
      京都
    • Year and Date
      2012-12-15
  • [Presentation] 保美貝塚出土人骨・獣骨の分析2012

    • Author(s)
      米田穣、太田博樹、日下宗一郎、覚張隆史、小山荘太郎
    • Organizer
      日本考古学協会、第78会総会研究発表プログラム
    • Place of Presentation
      大正大学大崎キャンパス、東京
    • Year and Date
      2012-05-27
  • [Presentation] 人類の形態、生理・代謝、疾患の進化に関するゲノム多様性研究2011

    • Author(s)
      太田博樹
    • Organizer
      統数研研究集会、統計数理学研究所
    • Place of Presentation
      立川
    • Year and Date
      20111219-20
  • [Presentation] Populations specific susceptibility To Crohn's disease and signals of natural selection on standing vari- Populations specific susceptibility To Crohn's disease and signals of natural selection on standing vari- ation (Poster)2011

    • Author(s)
      S. Nakagome, S. Mano, L. Kozlowski, J. M. Bujnicki, H. Shibata, Y. Fukumaki, J. R. Kidd, K. K. Kidd, S. Kawamura, H. Oota
    • Organizer
      The 12th ICHG/The 61th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      20111011-15
  • [Presentation] Toward understanding evolutionary force behind color vision poly- morphism in humans2011

    • Author(s)
      石崎直也、白井裕介、福世裕貴子、石田 肇、K.K.Kidd、太田博樹、河村正二
    • Organizer
      第13回日本進化学会
    • Place of Presentation
      京都大学百周年時計台記念館、京都
    • Year and Date
      20110729-31
  • [Presentation] Population specific distri- bution of Crohn's disease risk alleles on the NOD2locus and natu- ral selection on standing variation (Oral)2011

    • Author(s)
      S. Nakagome, S. Mano, L. Kozowski, J. M. Bujnicki, H. Shibata, Y. Fukumaki, J. R. Kidd, K. K. Kidd, S. Kawamura, H. Oota
    • Organizer
      The Society for Molecular Biology and Evolution Annual Meeting
    • Place of Presentation
      kyoto,Japan
    • Year and Date
      20110726-30
  • [Presentation] Toward Understanding Evolutionary Force behind Color Vision Polymorphism in Humans(Poster)2011

    • Author(s)
      N. Ishizaiki, Y. Shirai, Y. Fukuyo, H. Ishida, K. K. Kidd, H. Oota, S. Kawamura
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      20110726-30
  • [Presentation] An evolutionary study of human complex diseases (Invited)2011

    • Author(s)
      S. Nakagome, S. Mano, L. Kozlowski, J. M. Bujnicki, J. R. Kidd, S. Kawamura, H. Oota
    • Organizer
      Workshop on Evolutioary Analysis and Applications
    • Place of Presentation
      Xi'an and Lhasa, China
    • Year and Date
      20110607-20
  • [Presentation] 沖縄人が大和人より酒に強い理由-遺伝子を調べてわかったこと-2011

    • Author(s)
      太田博樹
    • Organizer
      第65回日本人類学会公開シンポジウム「琉球弧とヒトの適応戦略」
    • Place of Presentation
      那覇
    • Year and Date
      2011-11-06
  • [Presentation] How do physical anthropolo- gists have-committed themselves on genome medicine? Changing Representations of Indige- nous and Migrant Groups in Globali- zing Japan Genes,Bones, and Cultures2011

    • Author(s)
      H.Oota
    • Organizer
      IUAES/AAS/ASAANZ Conference 2011
    • Place of Presentation
      Perth,Australia
    • Year and Date
      2011-07-05
  • [Presentation] 環境要因と遺伝的多型と多 様な表現型との関係/Environmental factors and relationship between genetic polymorphisms and various phenotypes2011

    • Author(s)
      太田博樹
    • Organizer
      第64回日本生理人類学会シンポジウム「環境及び遺伝の要因と生理的多型との関係」
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-11
  • [Book] Evolutioary Insights into the "Population- Specificity"of the Genetic FactorsAssociated with Inflammatory BowelDiseases2012

    • Author(s)
      S.Nakagome,H.Oota
    • Total Pages
      222
  • [Book] Effects of Human Migration on Genome Diversity in East Asia2011

    • Author(s)
      H.Oota, M.Stoneking
    • Total Pages
      252

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Published: 2014-09-25   Modified: 2022-12-28  

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