2011 Fiscal Year Final Research Report
Creation of novel antimicrobial designed proteins against infectious pathogenic microorganisms
| Project/Area Number |
23658074
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011
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| Keywords | 抗真菌薬 / 抗菌ペプチド / デザインタンパク質医薬 / 感染症 / 真菌症 / Candida albicans / ペプチドライブラリー / プロテアーゼ感受性 |
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| Research Abstract |
Antimicrobial peptides(AMPs) are promising antibiotics as they possess strong antimicrobial activity and very broad spectra of activity. We designed a novel AMP. We utilized Candida albicans as a model organism that produces secreted aspartic proteases(Saps) as a virulence attribute. The designed peptide possessed no antimicrobial activity until it was activated by Sap isozymes. Furthermore, it demonstrated selective antimicrobial activity against C. albicans, but not against Saccharomyces cerevisiae.
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