2012 Fiscal Year Final Research Report
Chemical genomics using yeast essential genes for identifying target molecules/pathways of bioactive compounds
| Project/Area Number |
23658077
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ケミカルゲノミクス / ケミカルジェネティクス / 生育必須遺伝子 |
|---|
| Research Abstract |
There have been reported many natural and synthetic bioactive compounds. However, it is usually not easy to identify their target molecules and/or target pathways. T o overcome this difficulty, we tried to construct a semi-genome wide screen system using yeast as a model system. We show that semi-genome wide system is effective for predicting the target pathway of a bioactive compound, while informatics analysis utilizing gene-gene network is indispensable for constructing a versatile prediction system.
|
