2012 Fiscal Year Final Research Report
Why is lacticin Qa super-bacteriocin ?
| Project/Area Number |
23658081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Kyushu University |
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Principal Investigator |
SONOMOTO Kenji 九州大学, 大学院・農学研究院, 教授 (10154717)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 乳酸菌 / バクテリオシン / ラクティシンQ / 選択的抗菌活性 / Huge Toroidal Poreモデル / 膜電位崩壊 / 細胞膜成分 / レセプター |
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| Research Abstract |
Lacticin Q, a lactococcal pore (Huge Toroidal Pore)-forming bacteriocin, shows activity toward Gram-positive bacteria but not Gram-negative bacteria. Lacticin Q did not induce permeability of the outer membrane of Gram-negative bacteria. Experiments using model membranes containing outer membrane components suggested that lacticin Q binds to the outer membrane of Gram-negative bacteria but isunable to penetrate it. The lack of activity of lacticin Q was attributed to physicochemical features of the outer membrane components.
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