2012 Fiscal Year Final Research Report
Immunomodulation of functional food components via regulation of lipid rafts
| Project/Area Number |
23658113
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食品機能 |
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| Research Abstract |
We evaluated that the effects of 20 carotenoids on the function of immunocompetent cells. It was found that 6, 12 and 15 carotenods can suppress the reaction of mast cells, B cells and macrophage via their receptors, respectively. The translocation of the receptor to lipid rafts in each immunocompetent cell was inhibited by all carotenoids showing the suppression activity of the response by the ligand. These results suggested that the regulation of function in the immunocmpetent cells by carotenoids was due to the alteration of the location of the receptors and lipid rafts.
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