Advanced utilization of fermented food by-products: Development of Eco-immuno feeds"supporting health and environment

2012 Fiscal Year Final Research Report

• Project/Area Number: 23658216
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Zootechnical science/Grassland science
• Research Institution: Tohoku University
• Principal Investigator: KITAZAWA Haruki 東北大学, 大学院・農学研究科, 准教授 (10204885)
• Co-Investigator(Kenkyū-buntansha): ASO Hisashi 東北大学, 大学院・農学研究科, 教授 (50241625)
• Co-Investigator(Renkei-kenkyūsha): SUDA Yoshihito 宮城大学, 食産業学部, 准教授 (90404847)
• Project Period (FY): 2011 – 2012
• Keywords: 畜産物利用 / 発酵食品 / 未活用資源 / ブタ / イムノバイオティクス / イムノジェ ニクス / エコフィード

Research Abstract

In this study, for beneficial use of lactic acid bacterial fermentation liquid as underutilized resources, we focused on immunobiotics and immunogenics in the liquid and relating products, and examined fundamental analysis to develop as a novel “Immuno-Eco Feeds" contributing to the reduction of health hazards risk as livestock antimicrobial alternatives. Specifically, a safety of the liquid and immuneregulatory effects in porcine intestinal cells were evaluated, and in vivo confirmation study and in vitro detailed study of its mechanisms were also conducted.

Research Products

• [Journal Article] Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichiacoli-mediated inflammation (2013)
  • Author(s): Takanashi, N., Y. Tomosada, J. Villena, K. Murata, T. Takahashi, E. Chiba, M. Tohno, T. Shimazu, H. Aso, Y. Suda, S. Ikegami, H. Itoh, Y. Kawai, T. Saito, S. Alvarez, H. Kitazawa
  • Journal Title: BMC Microbiol Volume: 13(54) Pages: 1-16
  • DOI: DOI:10.1186/1471-2180-13-54.
  • Peer Reviewed
• [Journal Article] Immunobiotic Lactobacillus jensenii modulates toll-like receptor4-induced inflammatory response via negative regulation in porcine antigen presenting cells (2012)
  • Author(s): Villena, J., R. Suzuki, H. Fujie, E. Chiba, T. Takahashi, Y. Tomosada, T. Shimazu, H. Aso, S. Ohwada, Y. Suda, S. Ikegami, H. Itoh, S. Alvarez, T. Saito, H. Kitazawa
  • Journal Title: Clin. Vac. Immunol Volume: 19(7) Pages: 1038-1053
  • DOI: Doi:10.1128/CVI.00199-12.
  • Peer Reviewed
• [Journal Article] Lactobacillus plantarumNo.14株が生産する菌体外多糖の化学的性状と免疫活性 (2011)
  • Author(s): 橋口健司、長田裕子、吉田睦子、室伏陽、北澤春樹
  • Journal Title: 日本乳酸菌学会誌 Volume: 22(2) Pages: 100-105
  • URL: https://www.jstage.jst.go.jp/browse/jslab/
  • Peer Reviewed
• [Presentation] ブタの生産性を高めるイムノバイオティック乳酸菌の抗病性効果 (2013)
  • Author(s): 須田義人、下斗米陽子、細矢翔一、石田光晴、麻生久、牧野聖也、池上秀二、伊藤裕之、北澤春樹
  • Organizer: 日本畜産学会第116回大会
  • Place of Presentation: 広島
  • Year and Date: 20130328-30
• [Presentation] Role of pattern recognition receptors in the therapeutic effect of immunobiotics and immunogenics (2012)
  • Author(s): Kitazawa, H. , J. Villena
  • Organizer: LVII Reunion Cientifica Anual de la Sociedad Argentina de Investigacion Clinica, LX Reunion Cientifica Anual de la Sociedad Argentina de Inmunologia
  • Place of Presentation: Mar del Plata、Argentina(招待講演)
  • Year and Date: 20121114-17
• [Presentation] 乳酸菌菌体外多糖の異なるパターン認識受容体を介する免疫調節機能特性 (2012)
  • Author(s): 室伏陽、和知俊、細矢翔一、遠野雅徳、島津朋之、下里剛士、川井泰、齋藤忠夫、橋口健司、吉田睦子、北澤春樹
  • Organizer: 日本畜産学会第115回大会
  • Place of Presentation: 名古屋
  • Year and Date: 20120328-30
• [Presentation] 乳酸菌菌体外多糖のパターン認識受容体を介する免疫調節機能特性 (2012)
  • Author(s): 室伏陽、和知俊、細矢翔一、遠野雅徳、島津朋之、下里剛士、川井泰、齋藤忠夫、橋口健司、吉田睦子、北澤春樹
  • Organizer: 平成24年度酪農科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-08-18
• [Book] Nova Science Publishers, Inc. (2012)
  • Author(s): Villena, J., H. Aso, S. Alvarez, H. Kitazawa
  • Total Pages: 53-84
  • Publisher: Probiotics: Sources, Types and Health Benefits
• [Remarks]
  • URL: http://www.rpip.tohoku.ac.jp/seeds/profile/216