2012 Fiscal Year Final Research Report
Regulatory mechanisms of hydrogen sulfide in gastrointestinal functions: Is H2S an endogenous transmitter
| Project/Area Number |
23658230
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OTSUGURO Kenichi 北海道大学, 大学院・獣医学研究科, 准教授 (40344494)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Shigeo 北海道大学, 大学院・獣医学研究科, 教授 (40109509)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 硫化水素 / TRPA1 / 細胞内カルシウム / RIN14B / 知覚神経 / 5-HT |
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| Research Abstract |
The effects of an hydrogen sulfide (H2S) donor, NaHS, on the sensory neurons and model cells (RIN14B) for enterochromaffin cells were examined. H2S increased intracellular Ca2+ levels via the activation of TRPA1, resulting in neuronal excitation and secretory responses. The neuronal model PC12 cells expressed AST (aspartate aminotransferase)/MPST (mercaptopyruvate sulfurtransferase) and generated H2S. In the intestine, it is suggested that neuronal cells not only respond to intraluminal H2S but also synthetizes H2S to regulate gastrointestinal functions.
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