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2012 Fiscal Year Final Research Report

Identification of factors that involved in migration of mesenchymal stem cells to lesions of neurodegenerative diseases

Research Project

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Project/Area Number 23658233
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionHokkaido University

Principal Investigator

HORIUCHI Motohiro  北海道大学, 大学院・獣医学研究科, 教授 (30219216)

Project Period (FY) 2011 – 2012
Keywords骨髄由来間葉系幹細胞 / プリオン / 神経変性疾患 / 走化性 / ケモカイン
Research Abstract

In vitro migration assay was carried out to investigate chemoattractive factors for MSCs in the brain lesions of prion-infected mice. In addition, expression of chemokine receptor on MSCs that had been transplanted in the brain of prion-infected mice was analyzed. The combined in vitro and in vivo analyses suggest that CCR3, CCR5, CXCR3 and CXCR4 and their corresponding ligands are involved in the migration of hMSCs to the brain lesions caused by prion propagation.

  • Research Products

    (10 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Therapeutic effect of peripheral administration of an anti-prion protein antibody on mice infected with prions2013

    • Author(s)
      Ohsawa, N., Song, C.-H., Suzuki, A., Furuoka, H., Hasebe, R., and Horiuchi,M
    • Journal Title

      Microbiol. Immunol

      Volume: 57(4) Pages: 288-297

    • Peer Reviewed
  • [Journal Article] Characterization of intracellular localization of PrPSc in prion-infected cells using monoclonal antibody that recognizes the region consisting of amino acids 119-127 of mouse2012

    • Author(s)
      Yamasaki, T., Suzuki, A., Shimizu, T., Watarai, M., Hasebe, R. and Horiuchi, M
    • Journal Title

      PrP. J. Gen. Virol

      Volume: 93(Pt3) Pages: 668-680

    • Peer Reviewed
  • [Journal Article] Reaction of complement factors varies with prion strains in vitro and in vivo2012

    • Author(s)
      Hasebe, R., Raymond, G. J., Horiuchi, M., and Caughey, B
    • Journal Title

      Virology

      Volume: 423(2) Pages: 205-213

    • Peer Reviewed
  • [Journal Article] Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions2011

    • Author(s)
      Song C.-H., Honmou, O., Furuoka, H. and Horiuchi, M
    • Journal Title

      J. Virol

      Volume: 85(21) Pages: 11069-11078

    • Peer Reviewed
  • [Presentation] Construction of mAb132-EGFP fusion proteins as a PrPSc-specific probe2012

    • Author(s)
      Suzuki, A., Yamasaki, T., Hasebe, R., and Horiuchi, M
    • Organizer
      Asia Pacific Prion Symposium 2012
    • Place of Presentation
      Yokoyama,Japan
    • Year and Date
      20120729-30
  • [Presentation] Analysis of PrPSc accumulation and glial cell activationin brains of prion-infected mice at the early stage of infection2012

    • Author(s)
      Horiuchi, M, Yamasaki, T., Hasebe, R. and Takahashi, Y
    • Organizer
      Prion2012
    • Place of Presentation
      Amsterdam, The Netherland)UV University Amsterdam
    • Year and Date
      20120510-12
  • [Presentation] Detection of newly generataed PrPSc in Neuro2a cells inoculated with fluorescent-dye labeled purified PrPSc2011

    • Author(s)
      Yamasaki, T., Garon, G. B., and Horiuchi, M
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo, Japan Sapporo Convention Center
    • Year and Date
      20110911-16
  • [Presentation] Immunohistochemical analysis of PrPSc accumulation and activation of astrosytes and microglia in early stage of prion infection2011

    • Author(s)
      Takahashi, Y., Song, C.-H., Yamasaki, T., Hasebe, R., and Horiuchi, M
    • Organizer
      APPS2011
    • Place of Presentation
      Karuizawa,Japan Hotel Marroad Karuizawa
    • Year and Date
      20110710-11
  • [Book] プリオンの感染と細胞内動態2013

    • Author(s)
      山崎剛士、堀内基広
    • Total Pages
      215-224
    • Publisher
      Dementia Japan
  • [Book] プリオン病最新医学2011

    • Author(s)
      堀内基広
    • Total Pages
      2713-2720

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Published: 2014-09-25  

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