2012 Fiscal Year Final Research Report
Improvement of IVM based on the elucidation of meiosis pause mechanism by uppermost stream factor identification of oocyte maturation inhibitory factor group
| Project/Area Number |
23658236
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Eimei 東北大学, 大学院・農学研究科, 教授 (80093243)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHINO Yumi 東北大学, 大学院・農学研究科, 助教 (10451551)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 卵成熟 / 卵成熟抑制因子 / 減数分裂休止 / IVM |
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| Research Abstract |
We tried the elucidation for the global image of the meiosis pause mechanism seen in oocyte maturation process based on the previous results of research. The upstream factor was searched based on the data of a DNA microarray, and it was shown clearly that C-Type natriuretic peptide and adrenomedullin lead to identification of an upstream factor. Furthermore, we also tackled improvement of IVM and it was shown clearly that fertilizing capacity and the developmental competence after fertilization go up by in vitro oocyte maturation for a definite period of time by cAMP or a cAMP potentiation factor.
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