2013 Fiscal Year Final Research Report
Host cell factors to induce Toxoplasma gondii stage-conversion
| Project/Area Number |
23658239
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 潜伏 / トキソプラズマ |
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| Research Abstract |
Statistical difference of frequency of Toxoplasma gondii stage-conversion in normal fibroblast and a fibroblast cell line which had been transformed with MyoD. MyoD is key molecule to induce differentiation of myoblast, in which T. gondii preferencially converts its stage. Howevere, the result of this study indicates that MyoD expression is not enough to induce the stage-conversion.
In contrast, it was strongly suggested that p38 MAPK related with progression of stage-conversion from tachyzoite to bradyzoite.
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