2012 Fiscal Year Final Research Report
in vivo imaging of flavivirus encephalitis
| Project/Area Number |
23658243
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ウイルス / 脳神経疾患 / 獣医学 / 感染症 / 分子イメージング |
|---|
| Research Abstract |
In this study, we developed an in vivo imaging of flavivirusencephalitis using a mouse model. We inoculated Japanese encephalitis or Tick-borne encephalitis virus in mice, and compared accumulations of 18F-FDG between dying and surviving mice using positron emission tomography. Dying mice showed reduced levels of 18F-FDG uptakes in a part of brains compared with surviving mice. These results will provide useful information for clinical diagnosis of flavivirus encephalitis.
|
